TamoTREX 10® 100 tabs
Tamoxiphene Citrate 10mg/ 1tab

PubChem CID: 2733525
Chemical Names: Tamoxifen citrate; 54965-24-1; Istubal; Tamoxifen (Citrate); Zitazonium; UNII-7FRV7310N6   More…
Molecular Formula: C32H37NO8
Molecular Weight: 563.647 g/mol
InChI Key: FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Drug Information: Drug Indication  Clinical Trials  FDA Orange Book  FDA UNII
Safety Summary: Laboratory Chemical Safety Summary (LCSS)

One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.

Tamoxifen Citrate is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

TamoTREX 10® – Tamoxiphene Citrate 10mg/ 1tab , 100 tabs  More info