StanoTrex®150 10ml vial
Stanozolol Injection 150mg/ml, 10 mL Multidose Vial
Therapeutic Class:
Anabolic Agent
Composition:
Each 1 ml of STANOTREX150 contains
150 mg Stanozolol
Sterile Water Solution
For Intramuscular Administration
Indication & Dosage:
Stanozolol is used in the treatment of hereditary angioedema,
which causes episodes of swelling of the face, extremities,
genitals, bowel wall, and throat. Stanozolol may decrease the
frequency and severity of these attacks.
Oral
Vascular manifestations of Behcet’s syndrome
Adult: 10 mg daily.
Oral
Hereditary angioedema
Adult: Initially, 2.5-10 mg daily, reduced according to response.
Maintenance: 2 mg daily or on alternate days or 2.5 mg 3 times wkly.
Child: <6 yr: 1 mg daily; 6-12 yr: Up to 2 mg daily.
Intramuscular
Osteopetrosis
Adult: 50 mg every 2-3 wk.
Intramuscular
Anaemia
Adult: 50 mg every 2-3 wk.
Intramuscular
Breast cancer in postmenopausal women
Adult: 50 mg every 2-3 wk.
Intramuscular
Catabolic disorders
Adult: 50 mg every 2-3 wk..
Contraindications:
Heart or blood vessel disease; had a heart attack;
a high level of cholesterol in the blood; bleeding or blood clotting problems;
diabetes; using oral anticoagulant (blood thinner); liver problems; or kidney problems
Pregnancy and lactation; carcinoma of prostate or breast in men, hypercalcaemia, hypercalciuria, porphyria, severe hepatic impairment.
Special Precautions
Patients with cardiac, renal or hepatic disease, epilepsy or DM. Children, elderly.
Monitor liver function, haematocrit and haemoglobin concentrations. Not
recommended for treatment of hereditary angioedema in premenopausal women.
Adverse Drug Reactions
In rare cases, serious and even fatal cases of liver problems have developed
during treatment with stanozolol. Contact your doctor immediately if you experience
abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or
vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.
If you experience any of the following serious side effects, contact your doctor
immediately or seek emergency medical attention:an allergic reaction (difficulty breathing;
closing of the throat; swelling of the lips, tongue, or face; or hives);
swelling of the arms or legs (especially ankles); frequent or persistent erections, or
breast tenderness or enlargement (male patients); orvoice changes (hoarseness,
deepening), hair loss, facial hair growth, clitoral
enlargement, or menstrual irregularities (female patients).
Other less serious side effects may also occur. Talk to your doctor if you experience
new or worsening acne;difficulty sleeping;headache; orchanges in sexual desire.
Side effects other than those listed here may also occur. Talk to your doctor about
any side effect that seems unusual or that is especially bothersome.
Drug Interactions
Enhances activity of insulin, sulfonylureas, levothyroxine and anticoagulants e.g.
warfarin. May cause resistance to the effects of neuromuscular blockers.
Potentially Fatal: Enhances activity of insulin, sulfonylureas, levothyroxine and
anticoagulants e.g. warfarin. May cause resistance to the effects of neuromuscular blockers.
Pregnancy Category
Category X: Studies in animals or human beings have demonstrated foetal
abnormalities or there is evidence of foetal risk based on human experience
or both, and the risk of the use of the drug in pregnant women clearly
outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Mechanism of Action
Stanozolol is a structural analogue of testosterone which increases collagen
production and decreases the anti-anabolic action of cortisone. It is also reported
to reduce fibrin deposition. It corrects the formation of kinin or kinin-like factors
which may be associated with oedema and swelling seen in hereditary angioedema.
Metabolism: Hepatic.
Excretion: Urine (90%), faeces (6%).
Storage:
Store at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly-closed container. Store away from heat, moisture, and light.
Do not store in the bathroom. Keep out of the reach of children and away from pets.
Concentrex Laboratiories N. V., Moerstraat 58, 9031, Gent, Belgium
Reg. No. Licence: 253/55-C9/2010/BE
Manufactured under WHO cGMP guidelines
www.concentrexlabs.com
Date of Preparation : 19 july 2010